In The Bughouse Affair, former Pinkerton operative Sabina Carpenter and her detective partner, ex-Secret Service agent John Quincannon, undertake what initially appear to be two unrelated investigations. Sabinas case involves the hunt for a ruthless lady dip who uses fiendish means to relieve her victims of their valuables at Chutes Amusement Park and other crowded places. Quincannon, meanwhile, is after a slippery housebreaker who targets the homes of wealthy residents, following a trail that leads him from the infamous Barbary Coast to an oyster pirates lair to a Tenderloin parlor house known as the Fiddle Dee Dee. The two cases eventually connect in surprising fashion, but not before two murders and assorted other felonies complicate matters even further.