Free spirit Alys Seagraves and her elderly, eccentric friend Mame are about to embark upon an epic road trip across historic Route 66 when Mame suffers a medical setback that throws a wrench into their plans. Never the willing patient, Mame sneaks out of the hospital, determined to carry out her dangerous task while reliving memories along the famous highway. Now Alys has to trail the spunky senior westward and bring her back to reality—while dealing with Mame's uptight nephew, Elliot Ross.A sexy doctor and radio show personality, Elliot refuses to believe Mame or Alys can take care of themselves. Even though he possess a voice like velvet and eyes to match, he's hardheaded and determined to hospitalize Mame. The impromptu couple will be spending many hours together in an aging pink Cadillac—and the sparks are destined to fly.
