Fetal Alcohol Spectrum Disorders: Concepts, Mechanisms, and Cure (Neurology - Laboratory and Clinical Research Developments)

Alcoholism exerts a high genetic as well as epigenetic load and may be regarded as one of the most prevalent, identifiable, and preventable neuropsychiatric illnesses afflicting modern society today. Alcohol constituted 3.2% of all worldwide deaths in the year 2006 and is associated with >60 diseases, including fetal alcohol spectrum disorder (FASD) , cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders and life-threatening injuries. Fetal alcohol spectrum disorder (FASD) is a collective term representing fetal abnormalities associated with maternal alcohol abuse. The most unique feature of this book is that it introduces original concepts of mitochondrial bioenergetics, genomics, and epigenomics to successfully manage FASD. Particularly, mitochondrial bioenergetics-based CB prevention/inhibition, charnolophagy induction, and charnolophagosome and charnolosome stabilization are novel therapeutic targets for safe and effective clinical management of FASD. These c