On the waves of the North Atlantic, a poison spreads, sapping the life from humans and striking madness into immortals. Patrick Murphy, the immortal leader of Dublin, has been trying to stem the tide of Elixir washing into his territory, but nothing seems to stop the vampire drug. While others in the immortal world work to cure the creeping insanity that Elixir threatens, Murphy has been invited to London to join a summit of leaders hoping to discover who is shipping the drug. If Murphy and his allies can cut off the supply, they might be able to halt the spread long enough for a treatment to be found for the humans and vampires infected. Anne O'Dea, Murphy's former lover, retreated from public life over one hundred years ago to help immortals in need .